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ILPR G-Quadruplexes Formed in Seconds Demonstrate High Mechanical Stabilities.

The insulin linked polymorphism region (ILPR) is known to regulate transcription of the gene coding for insulin. The ILPR has guanine rich segments, suggesting that G quadruplexes may be responsible for this regulatory role. Using mechanical unfolding in a laser tweezers instrument and circular dich...

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Published in:Journal of the American Chemical Society Vol. 131; no. 5; pp. 1876 - 1883
Main Authors: Zhongbo Yu, Schonhoft, Joseph O., Dhakal, Soma, Bajracharya, Rabindra, Hegde, Ravi, Basu, Soumitra, Mao, Hanbin
Format: Article
Published: American Chemical Society 2/11/2009
Subjects:
Genetic transcription
Genetic code
Insulin
Quadruplex nucleic acids
Hypoglycemic agents
Spectrum analysis
Online Access:View this record in EBSCOhost

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