Introduction of Cationic Charge into DNA Near the Major Groove Edge of a Guanine•Cytosine Base Pair: Characterization of Oligodeoxynucleotides Substituted with 7-Aminomethyl-7-deaza-2′-deoxyguanosine.

The article presents a study on the synthesis of 7-aminomethyl-7-deaza-dG in the creation of a structural model of groove associated cations. The structural model has been used to be able to reflect cation distribution and location which has been observed in DNA structures. The study reveals its fin...

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Detalles Bibliográficos
Publicado en:	Journal of the American Chemical Society Vol. 131; no. 34; pp. 12068 - 12070
Autores principales:	Ganguly, Manjori, Ruo-Wen Wang, Marky, Luis A., Gold, Barry
Formato:	Artículo
Publicado:	American Chemical Society 9/2/2009
Materias:	Structural frame models Cations DNA Spectrum analysis Thermodynamics
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	The article presents a study on the synthesis of 7-aminomethyl-7-deaza-dG in the creation of a structural model of groove associated cations. The structural model has been used to be able to reflect cation distribution and location which has been observed in DNA structures. The study reveals its findings on the spectroscopic and thermodynamic characterization of DNA.