Mechanism of Glycan Receptor Recognition and Specificity Switch for Avian, Swine, and Human Adapted Influenza Virus Hemagglutinins: A Molecular Dynamics Perspective.

Hemagglutinins (HA's) from duck, swine, and human influenza viruses have previously been shown to prefer avian and human glycan receptor analogues with distinct topological profiles, pentasaccharides LSTa (α-2,3 linkage) and LSTc (α-2,6 linkage), in comparative molecular dynamics studies. On the bas...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 131; no. 47; pp. 17430 - 17443
Main Authors:	Newhouse, E. Irene, Dong Xu, Markwick, Phineus R. L., Amaro, Rommie E., Pao, Hsing C., Wu, Kevin J., Alam, Maqsudul, McCammon, J. Andrew, Li, Wilfred W.
Format:	Article
Published:	American Chemical Society 12/2/2009
Subjects:	Influenza Respiratory infections Hemagglutinin Immunity Blood agglutination Preventive medicine
Online Access:	View this record in EBSCOhost