All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia.
The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 microM for up to 96 hours...
| Publicado en: | Advances in Therapy Vol. 20; no. 6; pp. 337 - 344 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2003
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=49568443&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 49568443 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0741238X 1XDX jtl: Advances in Therapy issn: 0741238X maglogo: N pubinfo: dt: Nov2003 vid: 20 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 49568443 49568443 NLM15058751 49568443 10.1007/BF02849800 NLM15058751 49568443 ppf: 337 ppct: 7 formats: tig: atl: All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia. aug: au: Lin, Jen-Tsun Wu, Ming-Shiuan Wang, Wei-Shu Yen, Chueh-Chuan Chiou, Tzeon-Jye Liu, Jin-Hwang Yang, Mu-Hua Chao, Ta-Chon Chou, Shu-Chaou Chen, Po-Min affil: Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital , National Yang-Ming University, School of Medicine , #201, Sec 2, Shi-Pai Road 112 Shi-Pai, Taipei Taiwan sug: subj: Disease Susceptibility Receptors, Cell Surface Transcription Factors Leukemia, Promyelocytic, Acute Tretinoin Pharmacodynamics Genes Cell Division Physiology Reverse Transcriptase Polymerase Chain Reaction Methods Male Nucleotides Cell Division Drug Effects Proteins Human Female Documentation Sensitivity and Specificity Validation Studies Comparative Studies Evaluation Research Multicenter Studies Male Female ab: The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 microM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|