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Septal Infusions of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel (HCN-Channel) Blocker ZD7288 Impair Spontaneous Alternation But Not Inhibitory Avoidance.

Blockade of septal hyperpolarization-activated cyclic nucleotide-gated channels (HCN) impairs hippocampal theta, an effect that would be expected to impair memory. To test this hypothesis, the present experiments determined whether septal infusions of the selective HCN channel blocker ZD7288 would i...

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Published in:Behavioral Neuroscience Vol. 122; no. 3; pp. 549 - 557
Main Authors: Cissé, Ramata S., Krebs-Kraft, Desiree L., Parent, Marise B.
Format: Article
Published: American Psychological Association June 2008
Subjects:
Ion channels
Laboratory rats
Animal memory
Brain function localization
Online Access:View this record in EBSCOhost