Insulin Receptor Substrate-2 in the Ventral Tegmental Area Regulates Behavioral Responses to Cocaine.
Neurotrophic factor signaling modulates cellular and behavioral responses to drugs of abuse. Among other biochemical adaptations, chronic exposure to abused drugs decreases the expression of insulin receptor substrate-2 (IRS-2; a protein involved in neurotrophic signaling) in the ventral tegmental a...
| Publicado en: | Behavioral Neuroscience Vol. 122; no. 5; pp. 1172 - 1178 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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American Psychological Association
October 2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506848254&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506848254 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2008 vid: 122 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506848254 10.1037/a0012893 ppf: 1172 ppct: 6 formats: tig: atl: Insulin Receptor Substrate-2 in the Ventral Tegmental Area Regulates Behavioral Responses to Cocaine. aug: au: Iñiguez, Sergio D. Warren, Brandon L. Nestler, Eric J. Russo, Scott J. Neve, Rachael L. Bolaños-Guzmán, Carlos A. su: Rat behavior Brain function localization Drug abuse -- Animal models Growth factors sug: subj: Rat behavior Brain function localization Drug abuse -- Animal models Growth factors ab: Neurotrophic factor signaling modulates cellular and behavioral responses to drugs of abuse. Among other biochemical adaptations, chronic exposure to abused drugs decreases the expression of insulin receptor substrate-2 (IRS-2; a protein involved in neurotrophic signaling) in the ventral tegmental area (VTA), a neural substrate for many drugs of abuse. Using viral-mediated gene transfer to locally alter the activity of IRS-2, the authors show that overexpression of IRS-2 in the VTA results in an enhanced preference for environments previously paired with cocaine, as measured by the place conditioning paradigm, whereas blockade of IRS-2 activity results in avoidance of cocaine-paired compartments. In addition, IRS-2 overexpression leads to enhanced cocaine-induced locomotor activity, and blockade of IRS-2 expression significantly blunts behavioral responses to cocaine. These results demonstrate that levels of IRS-2 in the VTA regulate responsiveness to the behavioral effects of cocaine. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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