Insulin Receptor Substrate-2 in the Ventral Tegmental Area Regulates Behavioral Responses to Cocaine.

Neurotrophic factor signaling modulates cellular and behavioral responses to drugs of abuse. Among other biochemical adaptations, chronic exposure to abused drugs decreases the expression of insulin receptor substrate-2 (IRS-2; a protein involved in neurotrophic signaling) in the ventral tegmental a...

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Bibliographic Details

Published in:	Behavioral Neuroscience Vol. 122; no. 5; pp. 1172 - 1178
Main Authors:	Iñiguez, Sergio D., Warren, Brandon L., Nestler, Eric J., Russo, Scott J., Neve, Rachael L., Bolaños-Guzmán, Carlos A.
Format:	Article
Published:	American Psychological Association October 2008
Subjects:	Rat behavior Brain function localization Drug abuse > Animal models Growth factors
Online Access:	View this record in EBSCOhost