Hippocampus, III.

The writers discuss how neuronal signaling in the hippocampus is predominantly influenced by excitatory, glutamatergic neurons. They point out that the firing of these neurons is modulated by a relatively small number of γ-aminobutyric acid (GABA)-containing interneurons. They state that hippocamp...

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Detalles Bibliográficos
Publicado en:American Journal of Psychiatry Vol. 162; no. 3; pp. 450 - 451
Autores principales: Heckers, Stephan, Benes, Francine
Formato: Artículo
Publicado: American Psychiatric Publishing, Inc. March 2005
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Acceso en línea:Ver este registro en EBSCOhost
Descripción
Sumario:The writers discuss how neuronal signaling in the hippocampus is predominantly influenced by excitatory, glutamatergic neurons. They point out that the firing of these neurons is modulated by a relatively small number of γ-aminobutyric acid (GABA)-containing interneurons. They state that hippocampal function is determined by the balance between GABA-mediated inhibition and excitatory pyramidal cell firing. They conclude that glutamic acid decarboxylase is the rate-limiting enzyme.