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Atom-Economical Synthesis of N-Heterocycles via Cascade Inter-/Intramolecular C—N Bond-Forming Reactions Catalyzed by Ti Amides.

Direct and efficient catalytic reactions with excellent regioselectivity for the preparation of a series of substituted isoindoles, isoquinolines, and imidazoles are reported. Reaction of CH(2-CN)C≡C-R with an array of amines, catalyzed by 10 mol % of [ó:η:η-(OCH)(MeNCH)CBH]Ti(NMe) (1), gives a seri...

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Published in:Journal of the American Chemical Society Vol. 132; no. 33; pp. 11473 - 11481
Main Authors: Hao Shen, Zuowei Xie
Format: Article
Published: American Chemical Society 8/25/2010
Subjects:
Amides
Titanium
Catalysis
Chemical bonds
Indole
Isoquinoline
Amines
Online Access:View this record in EBSCOhost