The coagulopathy of cardiopulmonary bypass.

There have been numerous publications on the coagulopathy of cardiopulmonary bypass (CPB). This review provides an introduction to the history and main components of current CPB circuits and summarizes the current knowledge of pathogenesis, prevention, and treatment of the CPB coagulopathy. It encom...

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Bibliographic Details
Published in:Critical Reviews in Clinical Laboratory Sciences Vol. 47; no. 5/6; pp. 197 - 213
Main Authors: Besser, Martin W., Klein, Andrew A.
Format: algorithm pictorial review tables/charts Journal Article
Published: Taylor & Francis Ltd Sep-Dec2010
Online Access:View this record in EBSCOhost
Description
Summary:There have been numerous publications on the coagulopathy of cardiopulmonary bypass (CPB). This review provides an introduction to the history and main components of current CPB circuits and summarizes the current knowledge of pathogenesis, prevention, and treatment of the CPB coagulopathy. It encompasses an overview of intra- and postoperative monitoring of coagulation with special emphasis on the near-patient testing, its main complications, and the transfusion support, while taking into account the major changes in the technology used and supportive care provided since its inception.