Aggregation of Donor Base Stabilized 2-Thienyllithium in a Single Crystal and in Solution: Distances from X-ray Diffraction and the Nuclear Overhauser Effect.

Various 2-thienyllithium derivatives were investigated in the solid state by X-ray diffraction and in solution by 2D NMR experiments. The determined structures of [(EtO)Li(CHS)] (1), [(THF)Li(CHS)] (2), [(DME)Li(CHS)] (3), [(TMEDA)Li(CHS)] (4), and [(PMDETA)Li(CHS)] (5) (DME = 1,2-dimethoxyethane, T...

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Publicado en:Journal of the American Chemical Society Vol. 134; no. 2; pp. 1344 - 1352
Autores principales: Granitzka, Markus, Pöppler, Ann-Christin, Schwarze, Eike K., Stern, Daniel, Schulz, Thomas, John, Michael, Herbst-Irmer, Regine, Pandey, Sushil K., Stalke, Dietmar
Formato: Artículo
Publicado: American Chemical Society 1/18/2012
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Acceso en línea:Ver este registro en EBSCOhost
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        70786152
        10.1021/ja210382c
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        atl: Aggregation of Donor Base Stabilized 2-Thienyllithium in a Single Crystal and in Solution: Distances from X-ray Diffraction and the Nuclear Overhauser Effect.
      aug:
        au:
          Granitzka, Markus
          Pöppler, Ann-Christin
          Schwarze, Eike K.
          Stern, Daniel
          Schulz, Thomas
          John, Michael
          Herbst-Irmer, Regine
          Pandey, Sushil K.
          Stalke, Dietmar
        affil:
          Institut für Anorganische Chemie der Universität Göttingen, Tammannstrasse 4, 37077 Göttingen, Germany
          Department of Chemistry, University of Jammu, Jammu-180 006, India
      su:
        Optical diffraction
        X-rays
        Overhauser effect (Nuclear physics)
        Spectrum analysis
        Nitrogen
        Thiophenes
        Deuterium
      sug:
        subj:
          Optical diffraction
          X-rays
          Overhauser effect (Nuclear physics)
          Spectrum analysis
          Nitrogen
          Thiophenes
          Deuterium
      ab: Various 2-thienyllithium derivatives were investigated in the solid state by X-ray diffraction and in solution by 2D NMR experiments. The determined structures of [(EtO)Li(CHS)] (1), [(THF)Li(CHS)] (2), [(DME)Li(CHS)] (3), [(TMEDA)Li(CHS)] (4), and [(PMDETA)Li(CHS)] (5) (DME = 1,2-dimethoxyethane, TMEDA = N,N,N',N'-tetramethylethylene-1,2-diamine, and PMDETA = N,N,N',N?,N?-pentamethyldiethylenetriamine) were solved in nondonating toluene and provide firm ground for diffusion-ordered NMR spectroscopy as well as heteronuclear Overhauser enhancement NMR spectroscopy. The distance relation of nuclear Overhauser effects with a factor of r is employed to gain further insight into the aggregation degree of 1-5 in solution. Comparison of the slope provided by the linear region of the buildup curves and of the Σr calculated distances from the crystal structures offers a handle to judge the structure retention versus conversion in solution. The structures of 3-5 are maintained in toluene solution. The data of 2, however, indicate a partial dissociation or a rapid exchange between the vertices of a tetrameric core and free THF molecules. Auxiliary exchange spectroscopy investigations showed that the signals of the nitrogen donor base containing compounds 4 and 5 exchange with the signals of nonlithiatedthiophene. This is explained by exchange of the deuterium by a hydrogen atom via lithiation of toluene molecules.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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