The Moderating Effect of Alcohol-Specific Parental Rule-Setting on the Relation between the Dopamine D2 Receptor Gene (DRD2), the Mu-Opioid Receptor Gene (OPRM1) and Alcohol Use in Young Adolescents.

Aims: The main aim of the study was to test the moderating effect of two genetic polymorphisms, one in the dopamine D2 receptor gene (DRD2) and one in the mu-opioid receptor gene (OPRM1), on the link between parental rule-setting and adolescent alcohol use. Methods: A total of 214 adolescents (Mage...

Descripción completa

Detalles Bibliográficos
Publicado en:	Alcohol & Alcoholism Vol. 47; no. 6; pp. 663 - 671
Autores principales:	Pieters, Sara, Van Der Zwaluw, Carmen S., Van Der Vorst, Haske, Wiers, Reinout W., Smeets, Hubert, Lambrichs, Ellen, Burk, William J., Engels, Rutger C.m.e.
Formato:	research tables/charts Journal Article
Publicado:	Oxford University Press / USA Nov/Dec2012
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	Aims: The main aim of the study was to test the moderating effect of two genetic polymorphisms, one in the dopamine D2 receptor gene (DRD2) and one in the mu-opioid receptor gene (OPRM1), on the link between parental rule-setting and adolescent alcohol use. Methods: A total of 214 adolescents (Mage =13.7, 44.9% male) provided saliva samples and completed survey items describing alcohol use and parental rule-setting. Results: Findings indicated that alcohol-specific parental rule-setting was more robustly associated with alcohol use for adolescents with the DRD2 A1 risk allele and for those with the OPRM1 G-allele. Conclusion: This study replicates the interaction between parental rule-setting and the DRD2 risk allele on adolescent alcohol use and extends the literature by demonstrating the moderating effects of the OPRM1 risk allele on the link between parental rule-setting and adolescent alcohol use.