Electronic Measurements of Single-Molecule Processing by DNA Polymerase I (Klenow Fragment).

Bioconjugating single molecules of the Klenow fragment of DNA polymerase I into electronic nanocircuits allowed electrical recordings of enzymatic function and dynamic variability with the resolution of individual nucleotide incorporation events. Continuous recordings of DNA polymerase processing mu...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 135; no. 21; pp. 7855 - 7861
Main Authors:	Olsen, Tivoli J., Yongki Choi, Sims, Patrick C., Tolga Gul, O., Corso, Brad L., Chengjun Dong, Brown, William A., Collins, Philip G., Weiss, Gregory A.
Format:	Article
Published:	American Chemical Society 5/29/2013
Subjects:	DNA polymerases kinetics Single molecule research Biochemical templates Bioconjugates Electronic measurements Nucleotides Phosphodiesters
Online Access:	View this record in EBSCOhost