Extensive Reprogramming of the Genetic Code for Genetically Encoded Synthesis of Highly N-Alkylated Polycyclic Peptidomimetics.

Cyclic structures can increase the proteolytic stability and conformational rigidity of peptides, and N-alkylation of the peptide backbone can make peptides more cell-permeable and resistant to proteolysis. Therefore, cyclic N-alkyl amino acids are expected to be useful building blocks to increase s...

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Publicado en:	Journal of the American Chemical Society Vol. 135; no. 33; pp. 12297 - 12305
Autores principales:	Kawakami, Takashi, Ishizawa, Takahiro, Murakami, Hiroshi
Formato:	Artículo
Publicado:	American Chemical Society 8/21/2013
Materias:	Peptidomimetics Polycyclic compounds Genetic code Alkylation Proteolysis Amino acids Puromycin
Acceso en línea:	Ver este registro en EBSCOhost