Selective Detection and Inhibition of Active Caspase-3 in Cells with Optimized Peptides.

Caspases are a family of cysteine-aspartyl proteases that are well recognized for their essential roles in apoptosis and inflammation. Recently, caspases have also been linked to the promotion of other biologically important phenomena, such as cellular differentiation and proliferation. Dysregulatio...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 135; no. 34; pp. 12869 - 12877
Main Authors:	Vickers, Chris J., González-Páez, Gonzalo E., Wolan, Dennis W.
Format:	Article
Published:	American Chemical Society 8/28/2013
Subjects:	Caspases regulation Molecular probes Enzyme inhibitors Peptides Structural optimization Membrane permeability (Biology)
Online Access:	View this record in EBSCOhost