Phosphoryl Transfers of the Phospholipase D Superfamily: A Quantum Mechanical Theoretical Study.

The HKD-containing Phospholipase D superfamily catalyzes the cleavage of the headgroup of phosphatidylcholine to produce phosphatidic acid and choline. The mechanism of this cleavage process is studied theoretically. The geometric basis of our models is the X-ray crystal structure of the five-coordi...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 135; no. 37; pp. 13764 - 13775
Main Authors:	DeYonker, Nathan J., Webster, Charles Edwin
Format:	Article
Published:	American Chemical Society 9/18/2013
Subjects:	Hydrolysis Organic acids Density functionals Lipids Amino acids Vitamin B complex
Online Access:	View this record in EBSCOhost