Development of a Concise Synthesis of (+)-lngenol.

The complex diterpenoid (+)-ingenol possesses a uniquely challenging scaffold and constitutes the core of a recently approved anti-cancer drug. This full account details the development of a short synthesis of 1 that takes place in two separate phases (cyclase and oxidase) as loosely modeled after t...

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Publicado en:	Journal of the American Chemical Society Vol. 136; no. 15; pp. 5799 - 5811
Autores principales:	McKerrall, Steven J., Jørgensen, Lars, Kuttruff, Christian A., Ungeheuer, Felix, Baran, Phil S.
Formato:	Artículo
Publicado:	American Chemical Society 4/16/2014
Materias:	Diterpenes Cyclases Density functional theory Pinacol rearrangement Pinacols
Acceso en línea:	Ver este registro en EBSCOhost