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Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles.

A flow microreactor method for three-component coupling of benzyne was developed based on flash chemistry. o-Bromophenyllithium generated from 1- bromo-2-iodobenzene and a functionalized aryllithium generated from the corresponding aryl halide were mixed at —70 °C. In the subsequent reactor o-bromop...

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Published in:Journal of the American Chemical Society Vol. 136; no. 35; pp. 12245 - 12249
Main Authors: Aiichiro Nagaki, Daisuke Ichinari, Jun-ichi Yoshida
Format: Article
Published: American Chemical Society 9/3/2014
Subjects:
Benzynes
Electrophiles
Microreactors
Aryl halides
Chemical decomposition
Biogeochemical residence time
Chemical reactions
Online Access:View this record in EBSCOhost