Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats.
Aim: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. Methods: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (...
| Publicado en: | European Journal of Nutrition Vol. 54; no. 2; pp. 301 - 308 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103756127&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103756127 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2015 vid: 54 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103756127 100905498 10.1007/s00394-014-0711-2 NLM24821271 103756127 ppf: 301 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. aug: au: Sila, Assaâd Ghlissi, Zohra Kamoun, Zeineb Makni, Mohamed Nasri, Moncef Bougatef, Ali Sahnoun, Zouheir affil: Unité Enzymes et Bioconversio, Ecole Nationale d'Ingénieurs de Sfax, Université de Sfax, 3038 Sfax Tunisia sug: subj: Crustacea Carotenoids Pharmacodynamics Hypoglycemic Agents Pharmacodynamics Antioxidants Pharmacodynamics Kidney Drug Effects Tunisia Funding Source Animal Studies In Vivo Studies Rats Comparative Studies Creatinine Blood Urea Blood Uric Acid Blood Malondialdehyde Blood Kidney Analysis Malondialdehyde Analysis Histological Techniques Enzymes Analysis Superoxide Dismutase Analysis Glutathione Analysis Dietary Supplementation In Vitro Studies Models, Biological Staining and Labeling Data Analysis Software One-Way Analysis of Variance Post Hoc Analysis Descriptive Statistics P-Value Microscopy ab: Aim: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. Methods: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D+As) dissolved in olive oil and a diabetic group supplemented with olive oil (D+OO). In vitro antidiabetic effect was tested in plasma and kidney tissue. Results: The group D of rats showed significant ( P < 0.05) increase of glycemia, creatinine, urea and uric acid levels compared to those of the control group (C). Moreover, plasma and kidney malondialdehyde (MDA) and protein carbonyl (PCO) levels for the rats of the group D were significantly increased compared to the control group. Contrariwise, antioxidant enzyme activities, such as catalase (EC 1.11.1.6), superoxide dismutase (EC 1.15.1.1) and non-enzymatic levels of reduced glutathione, were significantly ( P < 0.05) decreased in the plasma and kidney of diabetic rats compared to the control ones. The astaxanthin supplementation in rats diet improved the antioxidant enzyme activities and significantly decreased the MDA and PCO levels compared to diabetic rats. Indeed, no significant ( P ≥ 0.05) improvement was observed for the fourth group (D+OO) compared to the control group (C). Histological analysis of kidney showed glomerular hypertrophy and tubular dilatation for the diabetic rats. For D+As rats, these histopathological changes were less prominent. Conclusions: Our results suggest that shrimp astaxanthin may play an important role in reduction of oxidative damage and could prevent pathological changes in diabetic rats suggesting promising application of shrimp astaxanthin in diabet treatment. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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