Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis.
Purpose: The Mediterranean diet rich in fruits, vegetables and olive oil has been related to a lower osteoporosis incidence and accordingly to a reduced fracture risk. These observations might be mediated by the active constituents of extra virgin olive oil, and especially polyphenols. In the contex...
| Publicado en: | European Journal of Nutrition Vol. 53; no. 4; pp. 1073 - 1082 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103951203&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103951203 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2014 vid: 53 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103951203 96201821 10.1007/s00394-013-0609-4 NLM24170065 103951203 ppf: 1073 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis. aug: au: Keiler, Annekathrin Zierau, Oliver Bernhardt, Ricardo Scharnweber, Dieter Lemonakis, Nikolaos Termetzi, Aikaterini Skaltsounis, Leandros Vollmer, Günter Halabalaki, Maria affil: Institute of Zoology, Molecular Cell Physiology and Endocrinology, Technische Universität Dresden, 01062 Dresden Germany sug: subj: Olive Oil Pharmacodynamics Osteoporosis Prevention and Control Polyphenols Pharmacodynamics Funding Source Female Postmenopause Simulations Animal Studies In Vivo Studies Rats Oophorectomy Receptors, Cell Surface Estrogens Uterus Analysis Body Weights and Measures Histological Techniques Progesterone Administration, Oral Dietary Supplementation Tomography, X-Ray Computed Bone Density Evaluation Descriptive Statistics One-Way Analysis of Variance Post Hoc Analysis T-Tests Food, Fortified Female ab: Purpose: The Mediterranean diet rich in fruits, vegetables and olive oil has been related to a lower osteoporosis incidence and accordingly to a reduced fracture risk. These observations might be mediated by the active constituents of extra virgin olive oil, and especially polyphenols. In the context of exploring the features of olive oil active constituents on postmenopausal osteoporosis, an extra virgin olive oil total polyphenolic fraction (TPF) was isolated and its effect on the bone loss attenuation was investigated. Methods: Female Lewis rats were ovariectomized and fed a diet enriched with a total phenolic extract of extra virgin olive oil in a concentration of 800 mg/kg diet. Results: Oleocanthal, one compound of the polyphenolic fraction, showed a higher relative estrogen receptor binding affinity to the ERα compared to the ERβ. While the TPF only slightly induced the uterine wet weight (490.7 ± 53.7 vs. 432.7 ± 23, p = 0.058), TPF regulated estrogen response genes in the uterus (progesterone receptor, antigen identified by monoclonal antibody Ki67, complement C3). Comparing the quantified bone parameters, the oral TPF substitution did not attenuate the ovariectomy-induced bone loss. Conclusions: The administration of extra virgin olive oil polyphenols regulated uterine estrogen response marker genes in an E2-agonistic manner. The bone loss induced by estrogen ablation was not mitigated by treatment with the polyphenolic extract. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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