Microsatellite Instability in Sarcoma: Fact or Fiction?
Microsatellite instability (MSI) is a unique molecular abnormality, indicative of a deficient DNA mismatch repair (MMR) system. Described and characterized in the colorectal cancer literature, the MSI-positive phenotype is predictive of disease susceptibility, pathogenesis, and prognosis. The clinic...
| Publicado en: | ISRN Oncology pp. 1 - 10 |
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| Autores principales: | , , , |
| Formato: | equations & formulas historical material pictorial review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104272093&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104272093 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20905661 BLI2 jtl: ISRN Oncology issn: 20905661 maglogo: N pubinfo: dt: 2012 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104272093 104272093 2012078957 104272093 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Microsatellite Instability in Sarcoma: Fact or Fiction? aug: au: Monument, Michael J. Lessnick, Stephen L. Schiffman, Joshua D. Randall, Rl. Tx. affil: Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA sug: subj: Sarcoma Physiopathology Genomics Funding Source History of Medicine Polymerase Chain Reaction Utilization Sarcoma, Ewing's ab: Microsatellite instability (MSI) is a unique molecular abnormality, indicative of a deficient DNA mismatch repair (MMR) system. Described and characterized in the colorectal cancer literature, the MSI-positive phenotype is predictive of disease susceptibility, pathogenesis, and prognosis. The clinical relevance of MSI in colorectal cancer has inspired similar inquisition within the sarcoma literature, although unfortunately, with very heterogeneous results. Evolving detection techniques, ill-defined sarcoma-specific microsatellite loci and small study numbers have hampered succinct conclusions. The literature does suggest that MSI in sarcoma is observed at a frequency similar to that of sporadic colorectal cancers, although there is little evidence to suggest that MSI-positive tumors share distinct biological attributes. Emerging evidence in Ewing sarcoma has demonstrated an intriguing mechanistic role of microsatellite DNA in the activation of key EWS/FLI-target genes. These findings provide an alternative perspective to the biological implications of microsatellite instability in sarcoma and warrant further investigation using sophisticated detection techniques, sensitive microsatellite loci, and appropriately powered study designs. pubtype: Academic Journal doctype: equations & formulas historical material pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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