Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.

The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a ‘haematological’ presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented wi...

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Publicado en:Clinical & Laboratory Haematology Vol. 27; no. 6; pp. 402 - 405
Autores principales: Mittal S, Milner BJ, Vickers MA
Formato: case study tracings Journal Article
Publicado: Wiley-Blackwell Dec2005
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.
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          Mittal S
          Milner BJ
          Vickers MA
        affil: Department of Clinical Haematology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK; sajjanmittal@yahoo.com
      sug:
        subj:
          Pyoderma Gangrenosum Diagnosis
          Splenomegaly Etiology
          T Lymphocytes
          Immunoglobulins Analysis
          Immunosuppression
          Male
          Middle Age
          Pyoderma Gangrenosum Physiopathology
          Pyoderma Gangrenosum Therapy
          Recurrence
          Splenectomy
          Middle Aged: 45-64 years
          Male
      ab: The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a ‘haematological’ presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal γ- and β-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.
      pubtype: Academic Journal
      doctype:
        case study
        tracings
        Journal Article
      ougenre: Article
    language: English
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