Cognitive flexibility and performance in children and adolescents with threshold and sub-threshold bipolar disorder.
Greater understanding of cognitive function in children and adolescents with bipolar disorder (BD) is of critical importance to improve our ability to design targeted treatments to help with real-world impairment, including academic performance. We sought to evaluate cognitive performance among chil...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 25; no. 6; pp. 625 - 639 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=115832080&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 115832080 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jun2016 vid: 25 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 115832080 115832080 115832080 10.1007/s00787-015-0769-2 115832080 ppf: 625 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Cognitive flexibility and performance in children and adolescents with threshold and sub-threshold bipolar disorder. aug: au: Dickstein, Daniel Axelson, David Weissman, Alexandra Yen, Shirley Hunt, Jeffrey Goldstein, Benjamin Goldstein, Tina Liao, Fangzi Gill, Mary Hower, Heather Frazier, Thomas Diler, Rasim Youngstrom, Eric Fristad, Mary Arnold, L. Findling, Robert Horwitz, Sarah Kowatch, Robert Ryan, Neal Strober, Michael affil: Department of Psychiatry, Nationwide Children's Hospital, Columbus USA sug: subj: Cognition In Infancy and Childhood Bipolar Disorder In Infancy and Childhood Task Performance and Analysis Human Child Adolescence Funding Source Cognition In Adolescence Bipolar Disorder In Adolescence Data Analysis Software Memory, Short Term Attention Post Hoc Analysis Clinical Assessment Tools Chi Square Test P-Value Male Female Multivariate Analysis of Variance Bipolar Disorder Drug Therapy Comorbidity Child: 6-12 years Adolescent: 13-18 years Male Female ab: Greater understanding of cognitive function in children and adolescents with bipolar disorder (BD) is of critical importance to improve our ability to design targeted treatments to help with real-world impairment, including academic performance. We sought to evaluate cognitive performance among children with either BD type I, II, or 'not otherwise specified' (NOS) participating in multi-site Course and Outcome of Bipolar Youth study compared to typically developing controls (TDC) without psychopathology. In particular, we sought to test the hypothesis that BD-I and BD-II youths with full threshold episodes of mania or hypomania would have cognitive deficits, including in reversal learning, vs. those BD-NOS participants with sub-threshold episodes and TDCs. N = 175 participants (BD-I = 81, BD-II = 11, BD-NOS = 28, TDC = 55) completed Cambridge Neuropsychological Automated Testing Battery (CANTAB) tasks. A priori analyses of the simple reversal stage of the CANTAB intra-/extra-dimensional shift task showed that aggregated BD-I/II participants required significantly more trials to complete the task than either BD-NOS participants with sub-syndromal manic/hypomanic symptoms or than TDCs. BD participants across sub-types had impairments in sustained attention and information processing for emotionally valenced words. Our results align with prior findings showing that BD-I/II youths with distinct episodes have specific alterations in reversal learning. More broadly, our study suggests that further work is necessary to see the interaction between neurocognitive performance and longitudinal illness course. Additional work is required to identify the neural underpinnings of these differences as targets for potential novel treatments, such as cognitive remediation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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