Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.

Background: The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found that chronic treatment with insulin analogues with high affinity towards the IGF1...

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Publicado en:	Breast Cancer Research Vol. 19; pp. 1 - 16
Autores principales:	Braak, Bas ter, Siezen, Christine L., Lee, Joo S., Rao, Pooja, Voorhoeve, Charlotte, Ruppin, Eytan, van der Laan, Jan Willem, van de Water, Bob, Ter Braak, Bas
Formato:	research Journal Article
Publicado:	BioMed Central 2/7/2017
Acceso en línea:	Ver este registro en EBSCOhost