Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.

Background: The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found that chronic treatment with insulin analogues with high affinity towards the IGF1...

Full description

Bibliographic Details

Published in:	Breast Cancer Research Vol. 19; pp. 1 - 16
Main Authors:	Braak, Bas ter, Siezen, Christine L., Lee, Joo S., Rao, Pooja, Voorhoeve, Charlotte, Ruppin, Eytan, van der Laan, Jan Willem, van de Water, Bob, Ter Braak, Bas
Format:	research Journal Article
Published:	BioMed Central 2/7/2017
Online Access:	View this record in EBSCOhost