Role of Heme Iron in the Association Between Red Meat Consumption and Colorectal Cancer.
The growing incidence of colorectal cancer (CRC) in the world seems to be related to the spread of Westernized lifestyles, particularly dietary habits. Several studies have found that high consumption of red meat—especially processed red meat, a mainstay of Western diets—is associated with an increa...
| Publicado en: | Nutrition & Cancer Vol. 70; no. 8; pp. 1173 - 1184 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov/Dec2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135800294&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135800294 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Nov/Dec2018 vid: 70 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 135800294 135800294 135800294 10.1080/01635581.2018.1521441 135800294 ppf: 1173 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Role of Heme Iron in the Association Between Red Meat Consumption and Colorectal Cancer. aug: au: Sasso, Arianna Latella, Giovanni affil: Division of Gastroenterology, Hepatology and Nutrition, Department of Life, Health, and Environmental Sciences, University of L'Aquila, L'Aquila, Italy sug: subj: Iron Adverse Effects Meat Adverse Effects Diet, Western Adverse Effects Colorectal Neoplasms Risk Factors Gut Microbiota Metabolism Epithelial Cells Metabolism Homeostasis ab: The growing incidence of colorectal cancer (CRC) in the world seems to be related to the spread of Westernized lifestyles, particularly dietary habits. Several studies have found that high consumption of red meat—especially processed red meat, a mainstay of Western diets—is associated with an increased risk of developing CRC. One possible reason for the association are the adverse effects exerted by the heme iron contained in red meat, which has the potential to affect homeostasis and colonic epithelial cell renewal and to promote the formation of mutagenic and carcinogenic agents. A correlation has also emerged between CRC and alterations of the gut microbiota, since the micro-organisms found in the intestinal lumen seem to influence the activation of enterocyte genes involved in the initiation and progression of carcinogenesis. Dietary habits can therefore modify the gut microbiota, affecting gene activation and favoring the development of cancer cells. We review and discuss the most recent literature on the hypothesis that heme iron can exert adverse effects by altering the gut microbiota and colorectal epithelial cell homeostasis. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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