Chronic refined low-fat diet consumption reduces cholecystokinin satiation in rats.
Purpose: Reduced ability of cholecystokinin (CCK) to induce satiation contributes to hyperphagia and weight gain in high-fat/high-sucrose (HF/HS) diet-induced obesity, and has been linked to altered gut microbiota. Rodent models of obesity use chow or low-fat (LF) diets as control diets; the latter...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 6; pp. 2497 - 2511 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138011375&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138011375 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2019 vid: 58 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138011375 138011375 138011375 10.1007/s00394-018-1802-2 138011375 ppf: 2497 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Chronic refined low-fat diet consumption reduces cholecystokinin satiation in rats. aug: au: Guerville, Mathilde Hamilton, M. Kristina Ronveaux, Charlotte C. Ellero-Simatos, Sandrine Raybould, Helen E. Boudry, Gaëlle affil: Institut Numecan, INRA INSERM Univ Rennes 1, Domaine de la Prise, 35590, Saint-Gilles, France sug: subj: Diet, Fat-Restricted Dietary Fats Pharmacodynamics Cholecystokinin Drug Effects Satiation Drug Effects Food Intake Animal Studies Rats Dietary Fats Dietary Sucrose Cellulose Cecum Metabolism Metabolomics Magnetic Resonance Spectroscopy Atrophy Signal Transduction ab: Purpose: Reduced ability of cholecystokinin (CCK) to induce satiation contributes to hyperphagia and weight gain in high-fat/high-sucrose (HF/HS) diet-induced obesity, and has been linked to altered gut microbiota. Rodent models of obesity use chow or low-fat (LF) diets as control diets; the latter has been shown to alter gut microbiota and metabolome. We aimed to determine whether LF-diet consumption impacts CCK satiation in rats and if so, whether this is prevented by addition of inulin to LF diet. Methods: Rats (n = 40) were fed, for 8 weeks, a chow diet (chow) or low-fat (10%) or high-fat/high-sucrose (45 and 17%, respectively) refined diets with either 10% cellulose (LF and HF/HS) or 10% inulin (LF-I and HF/HS-I). Caecal metabolome was assessed by 1H-NMR-based metabolomics. CCK satiation was evaluated by measuring the suppression of food intake after intraperitoneal CCK injection (1 or 3 µg/kg). Results: LF-diet consumption altered the caecal metabolome, reduced caecal weight, and increased IAP activity, compared to chow. CCK-induced inhibition of food intake was abolished in LF diet-fed rats compared to chow-fed rats, while HF/HS diet-fed rats responded only to the highest CCK dose. Inulin substitution ameliorated caecal atrophy, reduced IAP activity, and modulated caecal metabolome, but did not improve CCK-induced satiety in either LF- or HF/HS-fed rats. Conclusions: CCK signaling is impaired by LF-diet consumption, highlighting that caution must be taken when using LF diet until a more suitable refined control diet is identified. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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