Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects.

Purpose: To investigate whether the CYP3A4/5 and ABC transporter genetic polymorphisms could affect the pharmacokinetics of lenvatinib in Chinese healthy subjects. Methods: Thirty-two healthy Chinese volunteers were enrolled and took oral administration of 8 mg lenvatinib. Plasma concentration of le...

Full description

Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 76; no. 8; pp. 1125 - 1134
Main Authors:	Li, Jiaming, Wang, Xiaoqian, Ning, Chen, Wang, Zhaoyu, Wang, Yao, Zheng, Ming, Zhang, Siliang, Lu, Yang, Zhang, Yongjie, Li, Ning, Chen, Xijing, Zhao, Di
Format:	research tables/charts Journal Article
Published:	Springer Nature Aug2020
Online Access:	View this record in EBSCOhost