Imagen de Portada
Código QR

Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects.

With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconaz...

Descripción completa

Publicado en:Journal of Travel Medicine Vol. 29; no. 4; pp. 1 - 5
Autores principales: Thapar, Mita M, Ursing, Johan, Ashton, Michael, Bergqvist, Yngve, Gil, José Pedro, Björkman, Anders
Formato: Journal Article
Publicado: Oxford University Press / USA May2022
Acceso en línea:Ver este registro en EBSCOhost
Sumario:With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconazole compared to administration of atovaquone alone.