Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects.
With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconaz...
| Publicado en: | Journal of Travel Medicine Vol. 29; no. 4; pp. 1 - 5 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
May2022
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| Acceso en línea: | Ver este registro en EBSCOhost |