Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects.
With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconaz...
| Publicado en: | Journal of Travel Medicine Vol. 29; no. 4; pp. 1 - 5 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
May2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158041453&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158041453 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11951982 9O9 jtl: Journal of Travel Medicine issn: 11951982 maglogo: N pubinfo: dt: May2022 vid: 29 iid: 4 pid: 10398 pub: Oxford University Press / USA artinfo: ui: 158041453 158041453 NLM35532299 10.1093/jtm/taac058 NLM35532299 158041453 ppf: 1 ppct: 4 formats: tig: atl: Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects. aug: au: Thapar, Mita M Ursing, Johan Ashton, Michael Bergqvist, Yngve Gil, José Pedro Björkman, Anders affil: Principal PK Scientist , Quantitative Pharmacology & Pharmacometrics, Early Phase Services, ICON Clinical Research, Reading, UK sug: subj: Antimalarials Adverse Effects Malaria Drug Therapy Chloroguanide Adverse Effects Drug Combinations Research Subjects Ketoconazole Adverse Effects Atovaquone Adverse Effects ab: With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconazole compared to administration of atovaquone alone. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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