Milk fat globule membrane plus milk fat increase docosahexaenoic acid availability in infant formulas.
Purpose: Milk fat globule membrane (MFGM) has components with emulsifier properties that could affect the provision of substrates to the brain. We evaluated the effects of MFGM plus milk fat addition to infant formulas on docosahexaenoic acid (DHA) availability and gut development. Methods: In Exper...
| Published in: | European Journal of Nutrition Vol. 62; no. 2; pp. 833 - 846 |
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| Main Authors: | , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Mar2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161991411&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161991411 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2023 vid: 62 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161991411 159827175 161991411 161991411 10.1007/s00394-022-03024-5 161991411 ppf: 833 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Milk fat globule membrane plus milk fat increase docosahexaenoic acid availability in infant formulas. aug: au: Gázquez, Antonio Sabater-Molina, María Domínguez-López, Inés Sánchez-Campillo, María Torrento, Neus Tibau, Joan Moreno-Muñoz, José A. Rodríguez-Palmero, María López-Sabater, María C. Larqué, Elvira affil: Department of Physiology, University of Murcia, Campus Mare Nostrum, Murcia, Spain sug: subj: Infant Formula Docosahexaenoic Acids Fatty Acids Blood Gastrointestinal System Metabolism Animal Studies Animals Swine Funding Source Experimental Studies Cell Proliferation Physiology Apoptosis Physiology ab: Purpose: Milk fat globule membrane (MFGM) has components with emulsifier properties that could affect the provision of substrates to the brain. We evaluated the effects of MFGM plus milk fat addition to infant formulas on docosahexaenoic acid (DHA) availability and gut development. Methods: In Experiment 1, suckling piglets were divided into 3 groups: Group L1 (n = 8): fed with a vegetal fat formula with palm oil; L2 (n = 8): canola oil formula and L3 (n = 8): milk fat + canola oil + 1% Lacprodan (3% MFGM of total protein content). In Experiment 2, Group L4 (n = 7): fed with canola oil + 1% Lacprodan (3% MFGM) and Group L5 (n = 5): milk fat + canola oil + 2% Lacprodan (6% MFGM). All formulas contained 0.2% DHA and 0.2% arachidonic acid. Results: In Experiment 1, DHA was similar among the groups in both total fatty acids and plasma phospholipids (PL). However, 3% MFGM (L3) increased significantly the proportion of DHA and LC-PUFA n-3 in liver total fatty acids, jejunum, and also in jejunum PL respect to the other formulas. There were no changes in gut histology, cell proliferation, apoptosis, or brain DHA content. In Experiment 2, higher MFGM dose was used. Then, higher DHA was not only found in peripheral tissues of 6% MFGM (L5) piglets but also in plasma PL, while a similar trend was observed in cortex PL (p = 0.123). Conclusion: In conclusion, MFGM plus milk fat may increase DHA availability of infant formulas which could contribute to their beneficial health effects. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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