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The Influence of Probiotic Lactobacilli on COVID-19 and the Microbiota.

This comprehensive review explores the potential of using lactobacilli as a probiotic in the management of COVID-19. Our findings suggest that lactobacilli show promise in reducing the risk of death, gastrointestinal and overall symptoms, and respiratory failure, as well as in lowering cytokines and...

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Published in:Nutrients Vol. 16; no. 9; pp. 1350 - 1370
Main Authors: Taufer, Clarissa Reginato, da Silva, Juliana, Rampelotto, Pabulo Henrique
Format: research systematic review tables/charts Journal Article
Published: MDPI May2024
Online Access:View this record in EBSCOhost
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      dt: May2024
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      pub: MDPI
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        atl: The Influence of Probiotic Lactobacilli on COVID-19 and the Microbiota.
      aug:
        au:
          Taufer, Clarissa Reginato
          da Silva, Juliana
          Rampelotto, Pabulo Henrique
        affil: Graduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil
      sug:
        subj:
          Probiotics Therapeutic Use
          Lactobacillus
          Antiviral Agents Therapeutic Use
          COVID-19 Drug Therapy
          Disease Management
          Gut Microbiota Drug Effects
          Human
          Systematic Review
          Death Prevention and Control
          Signs and Symptoms, Digestive Prevention and Control
          Respiratory Failure Prevention and Control
          Cytokines Blood
          Biological Markers Blood
          Inflammation Mediators Blood
          Inflammation Prevention and Control
          Immunity
          Funding Source
          COVID-19 Prognosis
      ab: This comprehensive review explores the potential of using lactobacilli as a probiotic in the management of COVID-19. Our findings suggest that lactobacilli show promise in reducing the risk of death, gastrointestinal and overall symptoms, and respiratory failure, as well as in lowering cytokines and inflammatory markers associated with the disease. The molecular mechanisms by which lactobacilli protect against COVID-19 and other viral infections may be related to the reduction in inflammation, modulation of the immune response, and direct interaction with viruses to produce antiviral substances. However, the selected studies demonstrate the presence of mixed findings for various clinical, biochemical, hematological, and immunological parameters, which may be attributed to methodological differences among studies. We highlight the importance of clearly describing randomization processes to minimize bias and caution against small sample sizes and inappropriate statistical tests that could lead to errors. This review offers valuable insights into the therapeutic potential of lactobacilli in the context of COVID-19 and identifies avenues for further research and applications. These findings hold promise for the development of novel approaches to managing COVID-19 and warrant further investigation into the potential benefits of lactobacilli in combating the disease.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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