| Sumario: | Background: Extended reality (XR) has previously been used to train control of upper limb prostheses. It is however unclear what characteristics an XR environment should have in order to become a usable and effective training tool. Objective: The objective was to develop a framework describing the most important factors to be incorporated when designing an XR environment to train prosthesis control. Methods: A mixed method approach was used. A narrative review was conducted to explore factors that should be considered when designing an XR environment for prosthesis control. Subsequently, a preliminary framework, based on these factors, was rated by prosthesis users and therapists and discussed during focus groups. Results: Fifty out of 489 articles were included. The preliminary framework comprised 62 factors in four domains: feedback, control, exercise and environment. Five prosthesis users and eight therapists participated in three focus groups. A final framework was developed which contained 46 factors in the four domains. End-users considered all domains to be equally important, since domains and factors influence each other. Conclusions: The developed framework can be used to guide the design of an XR environment to train prosthesis control.
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