Natural Antimicrobial and Wound Healing Properties of Grape and Raisin Extracts: Insights from In Vitro Assays.
Background & Objective: This study examines the in vitro antimicrobial properties of black and yellow grape juice and raisin extracts against 12 Grampositive and Gram-negative bacterial strains, as well as five Candida species. Materials & Methods: Cell viability was assessed by MTT assay, antibacte...
| Publicado en: | Journal of Advances in Medical & Biomedical Research Vol. 34; no. 2; pp. 120 - 134 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
Mar/Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195814688&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195814688 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26766264 N5MJ jtl: Journal of Advances in Medical & Biomedical Research issn: 26766264 maglogo: N pubinfo: dt: Mar/Apr2026 vid: 34 iid: 2 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 195814688 195814688 195814688 10.30699/jambr.34.2.120 195814688 ppf: 120 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Natural Antimicrobial and Wound Healing Properties of Grape and Raisin Extracts: Insights from In Vitro Assays. aug: au: Jalilian, Farid Azizi Aghaei, Safoora Heidarzadi, Kobra Shokri, Somayeh Amini, Razieh Pakzad, Iraj Taherikalani, Morovat Mahmoudvand, Shahab Ansari, Nastaran Ramezannia, Zahra Keshavarzi, Amir Kalvandi, Gholamreza affil: Department of Medical Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. sug: subj: Antiinfective Agents Wound Healing Grape Plant Extracts Fruit Juices Cytotoxicity Tests, Immunologic Fibroblasts Analysis Biofilms Human Funding Source In Vitro Studies Descriptive Statistics Two-Way Analysis of Variance Patient Safety ab: Background & Objective: This study examines the in vitro antimicrobial properties of black and yellow grape juice and raisin extracts against 12 Grampositive and Gram-negative bacterial strains, as well as five Candida species. Materials & Methods: Cell viability was assessed by MTT assay, antibacterial activity by disk diffusion, MIC and MBC tests, biofilm inhibition by a microtiter plate method, and wound healing potential by a scratch assay. Results: MTT assay showed that black and yellow grape juices and yellow raisins were non-toxic up to 30 µg/mL, while black raisins were safe only up to 15 µg/mL. Disk diffusion demonstrated antibacterial activity of all extracts against most tested bacterial except A. baumannii and Methicillin-resistant S. aureus. The strongest inhibition zones were observed for P. aeruginosa, Enterococcus, S. epidermidis, L. monocytogenes, and S. maltophilia, varying by extract type, while E. coli and E. coli O157 showed the lowest sensitivity. None of the extracts showed antifungal activity against Candida species. The lowest MIC observed for the yellow and black raisin extracts was 15 µg/mL against Enterococcus and S. maltophilia. In the yellow and black grape juice, the lowest MIC against S. epidermidis, Enterococcus, and S. maltophilia was 30 µg/mL. Black grape juice showed the greatest inhibition of P. aeruginosa biofilm formation. Both yellow and black grape juices promoted wound healing. Conclusion: Grape extracts may serve as promising natural sources for the development of novel antibacterial agents against the tested Gram-positive and Gram-negative bacteria. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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