Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters.
The article discusses a study that introduces two different chemical reporters into sialic acid and N-acetylgalactosamine residues and then simultaneously imaged their associated cell surface glycans with fluorescent probes. In this study, the two chemical reporters used are the ketone and the azide...
| Publicado en: | Journal of the American Chemical Society Vol. 129; no. 27; pp. 8400 - 8402 |
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| Autores principales: | , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
7/11/2007
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | The article discusses a study that introduces two different chemical reporters into sialic acid and N-acetylgalactosamine residues and then simultaneously imaged their associated cell surface glycans with fluorescent probes. In this study, the two chemical reporters used are the ketone and the azide. Results reveal that glycan imaging can be realized using the bioorthogonal chemical reporter technique. This capability should enable monitoring of glycan expression and dynamics. |
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