Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters.
The article discusses a study that introduces two different chemical reporters into sialic acid and N-acetylgalactosamine residues and then simultaneously imaged their associated cell surface glycans with fluorescent probes. In this study, the two chemical reporters used are the ketone and the azide...
| Publicado en: | Journal of the American Chemical Society Vol. 129; no. 27; pp. 8400 - 8402 |
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| Autores principales: | , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
7/11/2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=25948042&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 25948042 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 7/11/2007 vid: 129 iid: 27 pid: 997 pub: American Chemical Society artinfo: ui: 25948042 10.1021/ja070238o ppf: 8400 ppct: 2 formats: tig: atl: Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters. aug: au: Chang, Pamela V. Prescher, Jennifer A. Hangauer, Matthew J. Bertozzi, Carolyn R. affil: Departments of Chemistry and Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, California 94720 su: Polysaccharides Azides Ketones Cell membranes Fluorescent probes Imaging systems Sialic acids sug: subj: Polysaccharides Azides Ketones Cell membranes Fluorescent probes Imaging systems Sialic acids ab: The article discusses a study that introduces two different chemical reporters into sialic acid and N-acetylgalactosamine residues and then simultaneously imaged their associated cell surface glycans with fluorescent probes. In this study, the two chemical reporters used are the ketone and the azide. Results reveal that glycan imaging can be realized using the bioorthogonal chemical reporter technique. This capability should enable monitoring of glycan expression and dynamics. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2007 holdings: @attributes: islocal: N |
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