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The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray Diffraction.

The article discusses a study on the catalytic mechanism of an aspartic proteinase, explored with neutron and x-ray diffraction. Aspartic proteinases have a proven therapeutic effect in the treatment of AIDS. Mechanistic proposals were made based on X-ray diffraction studies. The results suggest tha...

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Publicado en:Journal of the American Chemical Society Vol. 130; no. 23; pp. 7235 - 7238
Autores principales: Coates, Leighton, Han-Fang Tuan, Tomanicek, Stephen, Kovalevsky, Andrey, Mustyakimov, Marat, Erskine, Peter, Cooper, Jon
Formato: Artículo
Publicado: American Chemical Society 6/11/2008
Materias:
Aspartic proteinases
Optical diffraction
Neutrons
Catalysts
AIDS
Acceso en línea:Ver este registro en EBSCOhost
Sumario:The article discusses a study on the catalytic mechanism of an aspartic proteinase, explored with neutron and x-ray diffraction. Aspartic proteinases have a proven therapeutic effect in the treatment of AIDS. Mechanistic proposals were made based on X-ray diffraction studies. The results suggest that the transition state is stabilized by a negative charge on one of the catalytic aspartate residues.