The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray Diffraction.
The article discusses a study on the catalytic mechanism of an aspartic proteinase, explored with neutron and x-ray diffraction. Aspartic proteinases have a proven therapeutic effect in the treatment of AIDS. Mechanistic proposals were made based on X-ray diffraction studies. The results suggest tha...
| Publicado en: | Journal of the American Chemical Society Vol. 130; no. 23; pp. 7235 - 7238 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
6/11/2008
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=32820447&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 32820447 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 6/11/2008 vid: 130 iid: 23 pid: 997 pub: American Chemical Society artinfo: ui: 32820447 10.1021/ja801269x ppf: 7235 ppct: 3 formats: tig: atl: The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray Diffraction. aug: au: Coates, Leighton Han-Fang Tuan Tomanicek, Stephen Kovalevsky, Andrey Mustyakimov, Marat Erskine, Peter Cooper, Jon affil: Spallation Neutron Source, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831 Department of Chemistry, University of Toledo, Toledo, Ohio 53606 Bioscience Division, Mailsrop M888, Los Alanios National Laboratory, Los Alamos, New Mexico 87545 Laboratory for Protein Crystallography, Centre for Anzyloidosis and Acute Phase Proteins, Department of Medicine, University College London (Hampstead Campus), Rowland Hill Street, London NW3 2PF, U.K su: Aspartic proteinases Optical diffraction Neutrons Catalysts AIDS sug: subj: Aspartic proteinases Optical diffraction Neutrons Catalysts AIDS ab: The article discusses a study on the catalytic mechanism of an aspartic proteinase, explored with neutron and x-ray diffraction. Aspartic proteinases have a proven therapeutic effect in the treatment of AIDS. Mechanistic proposals were made based on X-ray diffraction studies. The results suggest that the transition state is stabilized by a negative charge on one of the catalytic aspartate residues. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2008 holdings: @attributes: islocal: N |
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