Detection of Single-Molecule DNA Hybridization Using Enzymatic Amplification in an Array of Femtoliter-Sized Reaction Vessels.

The article features a highly sensitive single-molecule readout system which detects deoxyribonucleic acid (DNA) hybridization using enzymatic signal amplification in an array of entoleter-sized reaction vessels. A fiber optic array was employed to validate the utility of the technology. An overview...

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Detalles Bibliográficos
Publicado en:Journal of the American Chemical Society Vol. 130; no. 38; pp. 12622 - 12624
Autores principales: Zhaohui Li, Hayman, Ryan B., Walt, David R.
Formato: Artículo
Publicado: American Chemical Society 9/24/2008
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Acceso en línea:Ver este registro en EBSCOhost
Descripción
Sumario:The article features a highly sensitive single-molecule readout system which detects deoxyribonucleic acid (DNA) hybridization using enzymatic signal amplification in an array of entoleter-sized reaction vessels. A fiber optic array was employed to validate the utility of the technology. An overview of the procedures of the experiment undertaken is also provided.