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Detection of Single-Molecule DNA Hybridization Using Enzymatic Amplification in an Array of Femtoliter-Sized Reaction Vessels.

The article features a highly sensitive single-molecule readout system which detects deoxyribonucleic acid (DNA) hybridization using enzymatic signal amplification in an array of entoleter-sized reaction vessels. A fiber optic array was employed to validate the utility of the technology. An overview...

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Published in:Journal of the American Chemical Society Vol. 130; no. 38; pp. 12622 - 12624
Main Authors: Zhaohui Li, Hayman, Ryan B., Walt, David R.
Format: Article
Published: American Chemical Society 9/24/2008
Subjects:
DNA
Molecular biology
Nucleic acid hybridization
Fiber optics
Array processors
Molecular genetics
Online Access:View this record in EBSCOhost

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