A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women.
Background: a small number of reports exist on the cognitive effects of soy isoflavones, the findings from which are mixed. Isoflavone efficacy is dependent upon conversion of glycosides contained in soy foods and supplements to the biologically active aglycons. Of particular interest is the product...
| Publicado en: | Age & Ageing Vol. 38; no. 1; pp. 86 - 94 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / UK
January 2009
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=511438907&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 511438907 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: January 2009 vid: 38 iid: 1 pid: 622 pub: Oxford University Press / UK artinfo: ui: 511438907 10.1093/ageing/afn227 ppf: 86 ppct: 8 formats: tig: atl: A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. aug: au: Gleason, Carey E. Carlsson, Cynthia M. Barnet, Jodi H. Meade, Sarah A. Setchell, Kenneth D. R. Atwood, Craig S. Johnson, Sterling C. Ries, Michele L. Asthana, Sanjay su: Flavonoids Nutrition Soybean Health of older people Dietary supplements sug: subj: Flavonoids Nutrition Soybean Health of older people Dietary supplements ab: Background: a small number of reports exist on the cognitive effects of soy isoflavones, the findings from which are mixed. Isoflavone efficacy is dependent upon conversion of glycosides contained in soy foods and supplements to the biologically active aglycons. Of particular interest is the production of the metabolite, equol, which is dependent upon intestinal microflora and an integrous digestive system, both being altered by age and age-associated conditions. Unfortunately, few studies enrolled adults over the age of 70, and none included older men. Objective: we examined safety, feasibility and cognitive efficacy of soy isoflavone administration in older nondemented men and women (age 62-89 years). Design and Methods: in this randomised, placebo-controlled, double-blind pilot study, subjects ingested either 100 mg/day soy isoflavones (glycoside weight) or matching placebo tablets for 6 months. Results: active and placebo-treated subjects exhibited a comparable side-effect profile. Plasma levels of genistein and daidzein (P < 0.001), but not equol, increased with isoflavone administration. While similar at baseline, the two groups differed across 6 months of treatment on 8 of 11 cognitive tests administered. Isoflavone-treated subjects improved on tests of visual-spatial memory (P < 0.01) and construction (P = 0.01), verbal fluency (P < 0.01) and speeded dexterity (P = 0.04). Placebo-treated participants were faster than isoflavone-treated subjects on two tests of executive function (P < 0.05). Conclusions: these data suggest that administration of 100 mg/day of isoflavones was well tolerated. Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration. Finally, data support the potential cognitive effects of soy isoflavones in older adults. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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