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Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation.

The article focuses on the sensor molecules consisting of covalent adducts of Ala-to-Cys mutants of the 140aa protein a-synuclein (AS) with thiol-reactive (maleimide) probe (MFC) based on 2-(2-furyl)-3-hydroxychromones (FC). It says that AS140-MFC is sensitive to the early and intermediate stages of...

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Publicado en:Journal of the American Chemical Society Vol. 132; no. 23; pp. 7860 - 7862
Autores principales: Yushchenko, Dmytro A., Fauerbach, Jonathan A., Thirunavukkuarasu, hyamala, Jares-Erijman, Elizabeth A., Jovin, Thomas M.
Formato: Artículo
Publicado: American Chemical Society 6/16/2010
Materias:
Thiols
Clustering of particles
Intermediates (Chemistry)
Molecules
Fire assay
Sampling (Process)
Protein synthesis
Acceso en línea:Ver este registro en EBSCOhost
Sumario:The article focuses on the sensor molecules consisting of covalent adducts of Ala-to-Cys mutants of the 140aa protein a-synuclein (AS) with thiol-reactive (maleimide) probe (MFC) based on 2-(2-furyl)-3-hydroxychromones (FC). It says that AS140-MFC is sensitive to the early and intermediate stages of the overall reaction. Meanwhile, the inherently continuous nature of the aggregation assay of MFC probe provides more detailed multiparameter data than thioflavin T (THT)-based sampling protocols.