Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation.
The article focuses on the sensor molecules consisting of covalent adducts of Ala-to-Cys mutants of the 140aa protein a-synuclein (AS) with thiol-reactive (maleimide) probe (MFC) based on 2-(2-furyl)-3-hydroxychromones (FC). It says that AS140-MFC is sensitive to the early and intermediate stages of...
| Publicado en: | Journal of the American Chemical Society Vol. 132; no. 23; pp. 7860 - 7862 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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American Chemical Society
6/16/2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=51796606&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 51796606 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 6/16/2010 vid: 132 iid: 23 pid: 997 pub: American Chemical Society artinfo: ui: 51796606 10.1021/ja102838n ppf: 7860 ppct: 2 formats: tig: atl: Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation. aug: au: Yushchenko, Dmytro A. Fauerbach, Jonathan A. Thirunavukkuarasu, hyamala Jares-Erijman, Elizabeth A. Jovin, Thomas M. affil: Laboratory of Cellular Dynamics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany Departamento de Qulmica Orgdnica, Facultad de Ciencias Exactas y Naturales, Uniuersidad de Buenos Aires, CIHIDECAR, CONICET, 1428 Buenos Aires, Argentina su: Thiols Clustering of particles Intermediates (Chemistry) Molecules Fire assay Sampling (Process) Protein synthesis sug: subj: Thiols Clustering of particles Intermediates (Chemistry) Molecules Fire assay Sampling (Process) Protein synthesis ab: The article focuses on the sensor molecules consisting of covalent adducts of Ala-to-Cys mutants of the 140aa protein a-synuclein (AS) with thiol-reactive (maleimide) probe (MFC) based on 2-(2-furyl)-3-hydroxychromones (FC). It says that AS140-MFC is sensitive to the early and intermediate stages of the overall reaction. Meanwhile, the inherently continuous nature of the aggregation assay of MFC probe provides more detailed multiparameter data than thioflavin T (THT)-based sampling protocols. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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