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Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair.

We report the discovery of a simple system through which variant pyrrolysyl-tRNA synthetase/ tRNA pairs created in Escherichia coli can be used to expand the genetic code of Saccharornyces care visiae. In the process we have solved the key challenges of producing a functional tRNA in yeast and disco...

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Published in:Journal of the American Chemical Society Vol. 132; no. 42; pp. 14819 - 14825
Main Authors: Hancock, Susan M., Uprety, Rajendra, Deiters, Alexander, Chin, Jason W.
Format: Article
Published: American Chemical Society 10/27/2010
Subjects:
Genetic code
Amino acids
Transfer RNA
Biosynthesis
Alkynes
Online Access:View this record in EBSCOhost