Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize.
We found that a flow microreactor system enables the generation of a configurationally unstable chiral organolithium intermediate and allows for its use in a reaction with an electrophile before it epimerizes. Based on this method, the enantioselective carbolithiation of conjugated enynes followed b...
| Publicado en: | Journal of the American Chemical Society Vol. 133; no. 11; pp. 3744 - 3748 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
3/23/2011
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |