Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize.

We found that a flow microreactor system enables the generation of a configurationally unstable chiral organolithium intermediate and allows for its use in a reaction with an electrophile before it epimerizes. Based on this method, the enantioselective carbolithiation of conjugated enynes followed b...

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Publicado en:	Journal of the American Chemical Society Vol. 133; no. 11; pp. 3744 - 3748
Autores principales:	Tomida, Yutaka, Nagaki, Aiichiro, Yoshida, Jun-ichi
Formato:	Artículo
Publicado:	American Chemical Society 3/23/2011
Materias:	Conjugated polymers Information asymmetry Enantioselective catalysis Microreactors Electrophiles
Acceso en línea:	Ver este registro en EBSCOhost