Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize.
We found that a flow microreactor system enables the generation of a configurationally unstable chiral organolithium intermediate and allows for its use in a reaction with an electrophile before it epimerizes. Based on this method, the enantioselective carbolithiation of conjugated enynes followed b...
| Publicado en: | Journal of the American Chemical Society Vol. 133; no. 11; pp. 3744 - 3748 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Chemical Society
3/23/2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=63149531&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 63149531 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 3/23/2011 vid: 133 iid: 11 pid: 997 pub: American Chemical Society artinfo: ui: 63149531 10.1021/ja110898s ppf: 3744 ppct: 4 formats: tig: atl: Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize. aug: au: Tomida, Yutaka Nagaki, Aiichiro Yoshida, Jun-ichi affil: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan su: Conjugated polymers Information asymmetry Enantioselective catalysis Microreactors Electrophiles sug: subj: Conjugated polymers Information asymmetry Enantioselective catalysis Microreactors Electrophiles ab: We found that a flow microreactor system enables the generation of a configurationally unstable chiral organolithium intermediate and allows for its use in a reaction with an electrophile before it epimerizes. Based on this method, the enantioselective carbolithiation of conjugated enynes followed by the reaction with electrophiles was accomplished to obtain enantioenriched chiral allenes. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2011 holdings: @attributes: islocal: N |
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