Discrete Bimodal Probes for Thrombus Imaging.
Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct imaging reporters at the C- and N-termini. In vitro studies demonstrated retention of fibrin affinity and spec...
| Publicado en: | Journal of the American Chemical Society Vol. 134; no. 26; pp. 10799 - 10803 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
7/4/2012
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=78021703&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 78021703 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 7/4/2012 vid: 134 iid: 26 pid: 997 pub: American Chemical Society artinfo: ui: 78021703 10.1021/ja3045635 ppf: 10799 ppct: 4 formats: tig: atl: Discrete Bimodal Probes for Thrombus Imaging. aug: au: Uppal, Ritika Ciesienski, Kate L. Chonde, Daniel B. Loving, Galen S. Caravan, Peter affil: A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, Massachusetts 02129, United States su: Diagnostic equipment Molecular probes Fibrin Thrombosis diagnosis Imaging systems Positron emission tomography Magnetic resonance imaging Optical images sug: subj: Diagnostic equipment Molecular probes Fibrin Thrombosis diagnosis Imaging systems Positron emission tomography Magnetic resonance imaging Optical images ab: Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct imaging reporters at the C- and N-termini. In vitro studies demonstrated retention of fibrin affinity and specificity. Imaging studies showed that these probes could detect fibrin over a wide range of probe concentrations by optical, magnetic resonance, and positron emission tomography imaging. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2012 holdings: @attributes: islocal: N |
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