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Discrete Bimodal Probes for Thrombus Imaging.

Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct imaging reporters at the C- and N-termini. In vitro studies demonstrated retention of fibrin affinity and spec...

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Published in:Journal of the American Chemical Society Vol. 134; no. 26; pp. 10799 - 10803
Main Authors: Uppal, Ritika, Ciesienski, Kate L., Chonde, Daniel B., Loving, Galen S., Caravan, Peter
Format: Article
Published: American Chemical Society 7/4/2012
Subjects:
Diagnostic equipment
Molecular probes
Fibrin
Thrombosis diagnosis
Imaging systems
Positron emission tomography
Magnetic resonance imaging
Optical images
Online Access:View this record in EBSCOhost

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